Nature Communications (Oct 2019)
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
- Jana K. Sonner,
- Melanie Keil,
- Maren Falk-Paulsen,
- Neha Mishra,
- Ateequr Rehman,
- Magdalena Kramer,
- Katrin Deumelandt,
- Julian Röwe,
- Khwab Sanghvi,
- Lara Wolf,
- Anna von Landenberg,
- Hendrik Wolff,
- Richa Bharti,
- Iris Oezen,
- Tobias V. Lanz,
- Florian Wanke,
- Yilang Tang,
- Ines Brandao,
- Soumya R. Mohapatra,
- Lisa Epping,
- Alexandra Grill,
- Ralph Röth,
- Beate Niesler,
- Sven G. Meuth,
- Christiane A. Opitz,
- Jürgen G. Okun,
- Christoph Reinhardt,
- Florian C. Kurschus,
- Wolfgang Wick,
- Helge B. Bode,
- Philip Rosenstiel,
- Michael Platten
Affiliations
- Jana K. Sonner
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Melanie Keil
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Maren Falk-Paulsen
- Institute of Clinical Molecular Biology, University Kiel
- Neha Mishra
- Institute of Clinical Molecular Biology, University Kiel
- Ateequr Rehman
- Institute of Clinical Molecular Biology, University Kiel
- Magdalena Kramer
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Katrin Deumelandt
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Julian Röwe
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Khwab Sanghvi
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Lara Wolf
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Anna von Landenberg
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Hendrik Wolff
- Molecular Biotechnology, Department of Biosciences and Buchmann Institute for Molecular Life Sciences (BMLS), Goethe-University Frankfurt
- Richa Bharti
- Institute of Clinical Molecular Biology, University Kiel
- Iris Oezen
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Tobias V. Lanz
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- Florian Wanke
- University Medical Center of the Johannes Gutenberg-University Mainz, Institute for Molecular Medicine
- Yilang Tang
- University Medical Center of the Johannes Gutenberg-University Mainz, Institute for Molecular Medicine
- Ines Brandao
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz
- Soumya R. Mohapatra
- Junior Group Brain Cancer Metabolism, German Cancer Research Center (DKFZ)
- Lisa Epping
- University Hospital Münster, Department of Neurology with Institute of Translational Neurology
- Alexandra Grill
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz
- Ralph Röth
- nCounter Core Facility, Institute of Human Genetics, University of Heidelberg
- Beate Niesler
- nCounter Core Facility, Institute of Human Genetics, University of Heidelberg
- Sven G. Meuth
- University Hospital Münster, Department of Neurology with Institute of Translational Neurology
- Christiane A. Opitz
- Junior Group Brain Cancer Metabolism, German Cancer Research Center (DKFZ)
- Jürgen G. Okun
- CCU Children’s Hospital and Metabolic Center Heidelberg
- Christoph Reinhardt
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz
- Florian C. Kurschus
- University Medical Center of the Johannes Gutenberg-University Mainz, Institute for Molecular Medicine
- Wolfgang Wick
- DKTK Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ)
- Helge B. Bode
- Molecular Biotechnology, Department of Biosciences and Buchmann Institute for Molecular Life Sciences (BMLS), Goethe-University Frankfurt
- Philip Rosenstiel
- Institute of Clinical Molecular Biology, University Kiel
- Michael Platten
- DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-019-12776-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of diet-regulated microbiota to prevent immune pathology.
