Nature Communications (Mar 2023)
Integrative proteogenomic characterization of early esophageal cancer
- Lingling Li,
- Dongxian Jiang,
- Qiao Zhang,
- Hui Liu,
- Fujiang Xu,
- Chunmei Guo,
- Zhaoyu Qin,
- Haixing Wang,
- Jinwen Feng,
- Yang Liu,
- Weijie Chen,
- Xue Zhang,
- Lin Bai,
- Sha Tian,
- Subei Tan,
- Chen Xu,
- Qi Song,
- Yalan Liu,
- Yunshi Zhong,
- Tianyin Chen,
- Pinghong Zhou,
- Jian-Yuan Zhao,
- Yingyong Hou,
- Chen Ding
Affiliations
- Lingling Li
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Dongxian Jiang
- Department of Pathology, Zhongshan Hospital Fudan University
- Qiao Zhang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Hui Liu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Fujiang Xu
- Department of Oncology, The Affiliated Hospital of Southwest Medical University
- Chunmei Guo
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Zhaoyu Qin
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Haixing Wang
- Department of Pathology, Zhongshan Hospital Fudan University
- Jinwen Feng
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yang Liu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Weijie Chen
- Department of Pathology, Zhongshan Hospital Fudan University
- Xue Zhang
- Department of Pathology, Zhongshan Hospital Fudan University
- Lin Bai
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Sha Tian
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Subei Tan
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Chen Xu
- Department of Pathology, Zhongshan Hospital Fudan University
- Qi Song
- Department of Pathology, Zhongshan Hospital Fudan University
- Yalan Liu
- Department of Pathology, Zhongshan Hospital Fudan University
- Yunshi Zhong
- Department of Pathology, Zhongshan Hospital Fudan University
- Tianyin Chen
- Department of Pathology, Zhongshan Hospital Fudan University
- Pinghong Zhou
- Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University
- Jian-Yuan Zhao
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yingyong Hou
- Department of Pathology, Zhongshan Hospital Fudan University
- Chen Ding
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/s41467-023-37440-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 28
Abstract
The progression of oesophageal squamous cell carcinoma (ESCC) from early to advanced stages requires comprehensive molecular characterisation. Here, the authors perform a proteogenomics analysis of ESCC patient samples across nine histopathological stages and three phases, identifying key alterations and paths for progression.
