DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the <i>APOE4</i> Genotype in Rodents

Abstract

Female APOE4 carriers have a greater predisposition to developing Alzheimer’s disease (AD) compared to their male counterparts, which may partly be attributed to menopause. We previously reported that a combination of menopause and APOE4 led to an exacerbation of cognitive and neurological deficits, which were associated with reduced brain DHA and DHA:AA ratio. Here, we explored whether DHA-enriched fish oil (FO) supplementation mitigated the detrimental impact of these risk factors. Whilst DHA-enriched fish oil improved recognition memory (NOR) in APOE4 VCD (4-vinylcyclohexene diepoxide)-treated mice (p Erβ, Cldn1 and Glut-5 expression in APOE4 mice receiving fish oil supplementation (p APOE4 female carriers.

Keywords

• Alzheimer’s disease
• apolipoprotein E
• arachidonic acid
• docosahexaenoic acid
• brain
• BDNF