Unravelling the developmental and functional significance of an ancient Argonaute duplication

Arie Fridrich; Vengamanaidu Modepalli; Magda Lewandowska; Reuven Aharoni; Yehu Moran

doi:10.1038/s41467-020-20003-8

Nature Communications (Dec 2020)

Unravelling the developmental and functional significance of an ancient Argonaute duplication

Arie Fridrich,
Vengamanaidu Modepalli,
Magda Lewandowska,
Reuven Aharoni,
Yehu Moran

Affiliations

Arie Fridrich: Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
Vengamanaidu Modepalli: Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
Magda Lewandowska: Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
Reuven Aharoni: Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem
Yehu Moran: Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s41467-020-20003-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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The sea anemone Nematostella vectensis expresses miRNAs and two Argonaute (AGO) proteins. Here the authors show that NveAGO1 and NveAGO2 are loaded with overlapping but different sets of miRNAs and that NveAGO2 binds both miRNAs and endo-siRNAs. Both AGO proteins are essential for development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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