Nature Communications (Oct 2017)

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

  • Mati Mann,
  • Arnav Mehta,
  • Jimmy L. Zhao,
  • Kevin Lee,
  • Georgi K. Marinov,
  • Yvette Garcia-Flores,
  • Li-Fan Lu,
  • Alexander Y. Rudensky,
  • David Baltimore

DOI
https://doi.org/10.1038/s41467-017-00972-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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MicroRNAs (miR) are important regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation. Here the authors show that NF-κB signalling, miR-155 and miR-146a form a complex network of cross-regulations to control gene transcription in macrophages for modulating inflammatory responses.