The giant protein titin regulates the length of the striated muscle thick filament

Paola Tonino; Balazs Kiss; Josh Strom; Mei Methawasin; John E. Smith; Justin Kolb; Siegfried Labeit; Henk Granzier

doi:10.1038/s41467-017-01144-9

Nature Communications (Oct 2017)

The giant protein titin regulates the length of the striated muscle thick filament

Paola Tonino,
Balazs Kiss,
Josh Strom,
Mei Methawasin,
John E. Smith,
Justin Kolb,
Siegfried Labeit,
Henk Granzier

Affiliations

Paola Tonino: Department of Cellular and Molecular Medicine, University of Arizona
Balazs Kiss: Department of Cellular and Molecular Medicine, University of Arizona
Josh Strom: Department of Cellular and Molecular Medicine, University of Arizona
Mei Methawasin: Department of Cellular and Molecular Medicine, University of Arizona
John E. Smith: Department of Cellular and Molecular Medicine, University of Arizona
Justin Kolb: Department of Cellular and Molecular Medicine, University of Arizona
Siegfried Labeit: Department of Integrative Pathophysiology, Medical Faculty Mannheim
Henk Granzier: Department of Cellular and Molecular Medicine, University of Arizona

DOI: https://doi.org/10.1038/s41467-017-01144-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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