Nature Communications (Mar 2016)

Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices

  • Juan A. Varela,
  • Julien P. Dupuis,
  • Laetitia Etchepare,
  • Agnès Espana,
  • Laurent Cognet,
  • Laurent Groc

DOI
https://doi.org/10.1038/ncomms10947
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Single quantum dot tracking is an established technique used in cultured neurons and organotypic brain slices. Here, the authors demonstrate in vivotargeting of dopamine receptors via ventricular injection of functionalized quantum dots and track single nanoparticle-receptors in acute rat brain slices.