Relapsed Mpox Keratitis, St. Louis, Missouri, USA

Abstract

We describe a case of a 46-year-old man in Missouri, USA, with newly diagnosed advanced HIV and PCR-confirmed mpox keratitis. The keratitis initially resolved after intravenous tecovirimat and penicillin for suspected ocular syphilis coinfection. Despite a confirmatory negative PCR, he developed relapsed, ipsilateral PCR-positive keratitis and severe ocular mpox requiring corneal transplant.

Keywords

• ocular mpox
• mpox keratitis
• ocular syphilis
• HIV
• AIDS
• monkeypox