Association of Cardiovascular Complications with Acute Phase Response in Kawasaki Patients

Abstract

Investigation of risk factors leading to cardiac complications in Kawasaki disease is extremely important because coronary vasculitis may lead to aneurysmal formation , stenosis and myocardial infarction. Various laboratory and clinical parameters have been investigated in order to find the predictive parameters and risk factors for such complications. In present study we addressed the relationship between intensity of acute phase response indicators(ESR, CRP, WBC and Platelet counts) and frequency of cardiovascular complications. 52 admitted children with Kawasaki disease were included in this retrospective study. Data regarding the intensity of acute phase reactants were recorded and relationships between these markers and frequency of cardiovascular problems were analyzed using statistical methods. Various cardiovascular abnormalities were demonstrated in 13 cases (25%) in whom, there were 11 cases with elevated ESR, 6 cases with positive CRP, 2 cases with leukocytosis and 4 cases with thrombocytosis but in comparison with non affected group , we didn’t find any significant correlation between cardiovascular and intensity of acute phase responses. The intensity of acute phase response indicators such as ESR, CRP, WBC and Platelet counts can not be regarded as useful predictors for cardiovascular complications of Kawasaki disease.

Keywords

• acute – phase reaction / heart diseases / mucocutaneous