Memorias do Instituto Oswaldo Cruz (Aug 2009)

Preparation and antitubercular activity of lipophilic diamines and amino alcohols

  • Celso OR Júnior,
  • Mireille Le Hyaric,
  • Cristiane F da Costa,
  • Taís A Corrêa,
  • Aline F Taveira,
  • Débora P Araújo,
  • Elaine FC Reis,
  • Maria Cristina S Lourenço,
  • Felipe RC Vicente,
  • Mauro V de Almeida

DOI
https://doi.org/10.1590/s0074-02762009000500006
Journal volume & issue
Vol. 104, no. 5
pp. 703 – 705

Abstract

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A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.

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