Efficient Synthesis of Pyrazinoic Acid Hybrid Conjugates

Abstract

Abstract Benzotriazole-activated pyrazinoic acid was utilized as a versatile building block for the efficient and convenient synthesis of novel hybrid conjugates of pyrazinoic acid with secondary amines via amino acid linkers in high yields.

Keywords

• pyrazinamide
• pyrazinoic acid
• secondary amines
• amino acids
• benzotriazole methodology
• antituberculosis