Effective treatment of refractory monoclonal gammopathy‐associated pure red cell aplasia with isatuximab, pomalidomide and dexamethasone

Abstract

Abstract Monoclonal gammopathy‐associated pure red cell aplasia (MG‐PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a monoclonal plasma cell dyscrasia. We report here on the successful treatment of MG‐PRCA with isatuximab, pomalidomide, and dexamethasone after multiple lines of immunosuppressive and anti‐plasma cell‐directed treatments.

Keywords

• MGUS
• multiple myeloma
• pure red cell aplasia