The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

John R. Horton; Clayton B. Woodcock; Sifa B. Opot; Norbert O. Reich; Xing Zhang; Xiaodong Cheng

doi:10.1038/s41467-019-12498-7

Nature Communications (Oct 2019)

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

John R. Horton,
Clayton B. Woodcock,
Sifa B. Opot,
Norbert O. Reich,
Xing Zhang,
Xiaodong Cheng

Affiliations

John R. Horton: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Clayton B. Woodcock: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Sifa B. Opot: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Norbert O. Reich: Department of Chemistry and Biochemistry, University of California
Xing Zhang: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Xiaodong Cheng: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-019-12498-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

CcrM is a cell cycle-regulated DNA methyltransferase that methylates an adenine within a specific sequence following replication in the gram negative bacterium Caulobacter crescentus. Here the authors present a crystal structure of DNA-bound CcrM that reveals the molecular mechanism leading to sequence-specific methylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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