Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication

Qiyue Mao; Akira T. Kawaguchi; Shun Mizobata; Roberto Motterlini; Roberta Foresti; Hiroaki Kitagishi

doi:10.1038/s42003-021-01880-1

Communications Biology (Mar 2021)

Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication

Qiyue Mao,
Akira T. Kawaguchi,
Shun Mizobata,
Roberto Motterlini,
Roberta Foresti,
Hiroaki Kitagishi

Affiliations

Qiyue Mao: Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
Akira T. Kawaguchi: Cell Transplantation and Regenerative Medicine, Tokai University
Shun Mizobata: Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
Roberto Motterlini: University Paris Est Creteil, INSERM, IMRB
Roberta Foresti: University Paris Est Creteil, INSERM, IMRB
Hiroaki Kitagishi: Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University

DOI: https://doi.org/10.1038/s42003-021-01880-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Mao et al. report highly sensitive quantification of carbon monoxide with a simple colorimetric assay, exploiting a synthetic supramolecular compound, hemoCD1. It can reveal distribution of CO in organs including the brain and can also serve as a CO scavenger for residual CO accumulated in organs. Finally, the authors showed circulating hemoglobin plays a protective role in CO intoxication.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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