High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature

A.-M. Globig; A. V. Hipp; P. Otto-Mora; M. Heeg; L. S. Mayer; S. Ehl; H. Schwacha; M. Bewtra; V. Tomov; R. Thimme; P. Hasselblatt; B. Bengsch

doi:10.1038/s41467-022-31229-z

Nature Communications (Jun 2022)

High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature

A.-M. Globig,
A. V. Hipp,
P. Otto-Mora,
M. Heeg,
L. S. Mayer,
S. Ehl,
H. Schwacha,
M. Bewtra,
V. Tomov,
R. Thimme,
P. Hasselblatt,
B. Bengsch

Affiliations

A.-M. Globig: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
A. V. Hipp: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
P. Otto-Mora: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
M. Heeg: Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg
L. S. Mayer: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
S. Ehl: Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg
H. Schwacha: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
M. Bewtra: Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine
V. Tomov: Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine
R. Thimme: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
P. Hasselblatt: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg
B. Bengsch: Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg

DOI: https://doi.org/10.1038/s41467-022-31229-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

The T cell compartment in patients with Crohn's disease is dysregulated. Here the authors use cytometric profiling to reveal an enrichment of distinct Tc17 cells during active Crohn's disease and may suggest CD6 as a potential target for therapeutic studies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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