Drug-Induced Parkinsonism and Neuroleptic Malignant Syndrome: A Case Report

Abstract

The article presents a clinical case of neuroleptic malignant syndrome (NMS) and DIP after a single dose of thiorizadine, and discusses the issues of differential diagnosis and treatment methods. A 57-year-old patient with long-term remission of schizophrenia due to insomnia was prescribed thiorizadine. After a single dose, symptoms of parkinsonism in the form of hypokinesia, muscle rigidity and bradyphrenia developed and began to progress. Three weeks later NMS developed, and treatment was carried out in the intensive care unit. When signs of parkinsonism persisted, she was hospitalized in the neurological department. Regression of symptoms occurred by her taking amantadine sulfate.

Keywords

• neuroleptic malignant syndrome
• drug-induced parkinsonism
• antipsychotic drugs
• parkinson’s disease