Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication

A.A. Khabarova; I.E. Pristyazhnyuk; T.V. Nikitina; T.A. Gayner; N.B. Torkhova; N.A. Skryabin; A.A. Kashevarova; N.P. Babushkina; Zh.G. Markova; M.E. Minzhenkova; L.P. Nazarenko; N.V. Shilova; A.R. Shorina; I.N. Lebedev; O.L. Serov

Stem Cell Research (Jan 2019)

Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication

A.A. Khabarova,
I.E. Pristyazhnyuk,
T.V. Nikitina,
T.A. Gayner,
N.B. Torkhova,
N.A. Skryabin,
A.A. Kashevarova,
N.P. Babushkina,
Zh.G. Markova,
M.E. Minzhenkova,
L.P. Nazarenko,
N.V. Shilova,
A.R. Shorina,
I.N. Lebedev,
O.L. Serov

Affiliations

A.A. Khabarova: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; Corresponding author.
I.E. Pristyazhnyuk: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
T.V. Nikitina: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
T.A. Gayner: Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia; Group of companies ''Center of new medical technologies'', Novosibirsk, Russia
N.B. Torkhova: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
N.A. Skryabin: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
A.A. Kashevarova: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
N.P. Babushkina: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Zh.G. Markova: Research Centre for Medical Genetics, Moscow, Russia
M.E. Minzhenkova: Research Centre for Medical Genetics, Moscow, Russia
L.P. Nazarenko: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
N.V. Shilova: Research Centre for Medical Genetics, Moscow, Russia
A.R. Shorina: Clinical City Hospital №1, Novosibirsk, Russia
I.N. Lebedev: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
O.L. Serov: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia

Journal volume & issue: Vol. 34

Abstract

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Skin fibroblasts from a patient with developmental delay and chromosome 2p25.3 deletion syndrome were reprogrammed into induced pluripotent stem cells (iPSCs) and the clonal stem cell line ICAGi001-A (iTAF9-11) was established. ICAGi001-A pluripotency was demonstrated in vitro by three germ layer differentiation capacity. This line is a good model for studying of the developmental delay and brain disorder.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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