Simultaneous optical and electrical in vivo analysis of the enteric nervous system

Nikolai Rakhilin; Bradley Barth; Jiahn Choi; Nini L. Muñoz; Subhash Kulkarni; Jason S. Jones; David M. Small; Yu-Ting Cheng; Yingqiu Cao; Colleen LaVinka; Edwin Kan; Xinzhong Dong; Michael Spencer; Pankaj Pasricha; Nozomi Nishimura; Xiling Shen

doi:10.1038/ncomms11800

Nature Communications (Jun 2016)

Simultaneous optical and electrical in vivo analysis of the enteric nervous system

Nikolai Rakhilin,
Bradley Barth,
Jiahn Choi,
Nini L. Muñoz,
Subhash Kulkarni,
Jason S. Jones,
David M. Small,
Yu-Ting Cheng,
Yingqiu Cao,
Colleen LaVinka,
Edwin Kan,
Xinzhong Dong,
Michael Spencer,
Pankaj Pasricha,
Nozomi Nishimura,
Xiling Shen

Affiliations

Nikolai Rakhilin: School of Electrical and Computer Engineering, Cornell University
Bradley Barth: Department of Biomedical Engineering, Cornell University
Jiahn Choi: Department of Biomedical Engineering, Cornell University
Nini L. Muñoz: School of Electrical and Computer Engineering, Cornell University
Subhash Kulkarni: Department of Medicine, Center for Neurogastroenterology, Johns Hopkins University
Jason S. Jones: Department of Biomedical Engineering, Cornell University
David M. Small: Department of Biomedical Engineering, Cornell University
Yu-Ting Cheng: Department of Biomedical Engineering, Cornell University
Yingqiu Cao: School of Electrical and Computer Engineering, Cornell University
Colleen LaVinka: Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Center for Sensory Biology, Johns Hopkins University School of Medicine
Edwin Kan: School of Electrical and Computer Engineering, Cornell University
Xinzhong Dong: Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Center for Sensory Biology, Johns Hopkins University School of Medicine
Michael Spencer: School of Electrical and Computer Engineering, Cornell University
Pankaj Pasricha: Department of Medicine, Center for Neurogastroenterology, Johns Hopkins University
Nozomi Nishimura: Department of Biomedical Engineering, Cornell University
Xiling Shen: School of Electrical and Computer Engineering, Cornell University

DOI: https://doi.org/10.1038/ncomms11800
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

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The enteric nervous system (ENS) plays a key role in regulating gut motility and homeostasis yet it remains a challenging system to record from. Here, the authors develop a novel abdominal window permitting simultaneous optical and electrical recording of mouse ENS system activity over prolonged time periods.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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