Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents

Veeranjaneyulu Pattabi; Madhu Raju Veeraboina; Laxminarayana Eppakayala; Srinivasu Navuluri; Naveen Mulakayala

Results in Chemistry (Jan 2024)

Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents

Veeranjaneyulu Pattabi,
Madhu Raju Veeraboina,
Laxminarayana Eppakayala,
Srinivasu Navuluri,
Naveen Mulakayala

Affiliations

Veeranjaneyulu Pattabi: Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, India
Madhu Raju Veeraboina: Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, India
Laxminarayana Eppakayala: Department of Chemistry, Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad 501301 India
Srinivasu Navuluri: Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; Corresponding authors.
Naveen Mulakayala: SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, India; Corresponding authors.

Journal volume & issue: Vol. 7
p. 101442

Abstract

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A library of aryl urea oxazole-pyrimidine derivatives (12a-j) have been synthesized and investigated for their anticancer activity profile against a panel of four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing of MTT method, compare with etoposide used as reference drug candidate. All the examined compounds displayed potent anticancer activity with IC50 values ranges from 0.01 ± 0.0062 µM to 10.6 ± 7.43 µM, whereas, etoposide showed values ranges from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among the synthesized compounds, seven compounds 12a, 12b, 12d, 12e, 12f, 12 g and 12 h demonstrated most promising activity than reference drug.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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