Nature Communications (Mar 2023)
Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis
- Qiang Yu,
- Igor Gamayun,
- Philipp Wartenberg,
- Qian Zhang,
- Sen Qiao,
- Soumya Kusumakshi,
- Sarah Candlish,
- Viktoria Götz,
- Shuping Wen,
- Debajyoti Das,
- Amanda Wyatt,
- Vanessa Wahl,
- Fabien Ectors,
- Kathrin Kattler,
- Daniela Yildiz,
- Vincent Prevot,
- Markus Schwaninger,
- Gaetan Ternier,
- Paolo Giacobini,
- Philippe Ciofi,
- Timo D. Müller,
- Ulrich Boehm
Affiliations
- Qiang Yu
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Igor Gamayun
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Philipp Wartenberg
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Qian Zhang
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD)
- Sen Qiao
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Soumya Kusumakshi
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Sarah Candlish
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Viktoria Götz
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Shuping Wen
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Debajyoti Das
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Amanda Wyatt
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Vanessa Wahl
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Fabien Ectors
- FARAH Mammalian Transgenics Platform, Liège University
- Kathrin Kattler
- Department of Genetics, Saarland University
- Daniela Yildiz
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Vincent Prevot
- Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172
- Markus Schwaninger
- Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck
- Gaetan Ternier
- Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172
- Paolo Giacobini
- Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172
- Philippe Ciofi
- Neurocentre Magendie - INSERM Unit 1215, University of Bordeaux
- Timo D. Müller
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD)
- Ulrich Boehm
- Department of Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37099-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
The median eminence (ME) at the base of the brain controls body homeostasis. Here, the authors describe a functional tanycyte subpopulation at the ME which tastes the surrounding milieu, responds to metabolic signals and regulates glucose homeostasis.
