Michael addition reaction in C-5 of Camptothecin

Changkuo Zhao; Linming Zuo; Xi Ke; Xianheng Wang

Journal of Saudi Chemical Society (May 2024)

Michael addition reaction in C-5 of Camptothecin

Changkuo Zhao,
Linming Zuo,
Xi Ke,
Xianheng Wang

Affiliations

Changkuo Zhao: Department of Medicinal Chemistry, Zunyi Medical University, No.6 Xue Fu West Road, Zunyi City 563003, Guizhou Province, China
Linming Zuo: Department of Medicinal Chemistry, Zunyi Medical University, No.6 Xue Fu West Road, Zunyi City 563003, Guizhou Province, China
Xi Ke: College of Health, Hubei Engineering Institute, No.366 Daqi Avenue East, Tieshan District, Huangshi Development District, Hubei Province 435000, China
Xianheng Wang: Department of Medicinal Chemistry, Zunyi Medical University, No.6 Xue Fu West Road, Zunyi City 563003, Guizhou Province, China; Corresponding author.

Journal volume & issue: Vol. 28, no. 3
p. 101867

Abstract

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A simple method for Michael addition at C-5 of Camptothecin has been developed to construct 5-CPT derivatives. The addition products were obtained with moderate yields, and the structures of the target compounds were characterized by 1H NMR, 13C NMR, and HRMS spectra. The feasibility of various Michael addition acceptors for this reaction has also been investigated.

Published in Journal of Saudi Chemical Society

ISSN: 1319-6103 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/journal-of-saudi-chemical-society/

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