BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Xiaofeng Wang; Su Wang; Emma C. Troisi; Thomas P. Howard; Jeffrey R. Haswell; Bennett K. Wolf; William H. Hawk; Pilar Ramos; Elaine M. Oberlick; Evgeni P. Tzvetkov; Aaron Ross; Francisca Vazquez; William C. Hahn; Peter J. Park; Charles W. M. Roberts

doi:10.1038/s41467-019-09891-7

Nature Communications (Apr 2019)

BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Xiaofeng Wang,
Su Wang,
Emma C. Troisi,
Thomas P. Howard,
Jeffrey R. Haswell,
Bennett K. Wolf,
William H. Hawk,
Pilar Ramos,
Elaine M. Oberlick,
Evgeni P. Tzvetkov,
Aaron Ross,
Francisca Vazquez,
William C. Hahn,
Peter J. Park,
Charles W. M. Roberts

Affiliations

Xiaofeng Wang: Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College
Su Wang: Department of Biomedical Informatics, Harvard Medical School
Emma C. Troisi: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Thomas P. Howard: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Jeffrey R. Haswell: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Bennett K. Wolf: Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College
William H. Hawk: Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College
Pilar Ramos: Comprehensive Cancer Center and Department of Oncology, St. Jude Children’s Research Hospital
Elaine M. Oberlick: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Evgeni P. Tzvetkov: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Aaron Ross: Comprehensive Cancer Center and Department of Oncology, St. Jude Children’s Research Hospital
Francisca Vazquez: Broad Institute of Harvard and MIT
William C. Hahn: Broad Institute of Harvard and MIT
Peter J. Park: Department of Biomedical Informatics, Harvard Medical School
Charles W. M. Roberts: Department of Pediatric Oncology, Dana-Farber Cancer Institute

DOI: https://doi.org/10.1038/s41467-019-09891-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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