Viruses (Mar 2023)

The Omicron Lineages BA.1 and BA.2 (<i>Betacoronavirus</i> SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub

  • Alessandra P. Lamarca,
  • Ueric José Borges de Souza,
  • Filipe Romero Rebello Moreira,
  • Luiz G. P. de Almeida,
  • Mariane Talon de Menezes,
  • Adrieli Barboza de Souza,
  • Alessandro Clayton de Souza Ferreira,
  • Alexandra L. Gerber,
  • Aline B. de Lima,
  • Ana Paula de C. Guimarães,
  • Andréa Cony Cavalcanti,
  • Aryel B. Paz e Silva,
  • Bruna Israel Lima,
  • Cirley Lobato,
  • Cristiane Gomes Da Silva,
  • Cristiane P. T. B. Mendonça,
  • Daniel Costa Queiroz,
  • Danielle Alves Gomes Zauli,
  • Diego Menezes,
  • Fábio Sossai Possebon,
  • Franciano Dias Pereira Cardoso,
  • Frederico Scott Varella Malta,
  • Isabela Braga-Paz,
  • Joice do Prado Silva,
  • Jorge Gomes Goulart Ferreira,
  • Jucimária Dantas Galvão,
  • Leandro Magalhães de Souza,
  • Leonardo Ferreira,
  • Lia Gonçalves Possuelo,
  • Liliane Tavares de Faria Cavalcante,
  • Luige B. Alvim,
  • Luiz Fellype Alves de Souza,
  • Luiza C. G. de Araújo E Santos,
  • Rillery Calixto Dias,
  • Rutilene Barbosa Souza,
  • Thaís Regina y Castro,
  • Andréia Rosane de Moura Valim,
  • Fabrício Souza Campos,
  • João Pessoa Araujo,
  • Priscila de Arruda Trindade,
  • Renato S. Aguiar,
  • Robson Michael Delai,
  • Ana Tereza R de Vasconcelos

DOI
https://doi.org/10.3390/v15040888
Journal volume & issue
Vol. 15, no. 4
p. 888

Abstract

Read online

Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation.

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