Nature Communications (Aug 2021)
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
- Clément Bodineau,
- Mercedes Tomé,
- Sarah Courtois,
- Ana S. H. Costa,
- Marco Sciacovelli,
- Benoit Rousseau,
- Elodie Richard,
- Pierre Vacher,
- Carlos Parejo-Pérez,
- Emilie Bessede,
- Christine Varon,
- Pierre Soubeyran,
- Christian Frezza,
- Piedad del Socorro Murdoch,
- Victor H. Villar,
- Raúl V. Durán
Affiliations
- Clément Bodineau
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Universidad Pablo de Olavide
- Mercedes Tomé
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Universidad Pablo de Olavide
- Sarah Courtois
- Bordeaux Research in Translational Oncology, INSERM U1053, Université de Bordeaux
- Ana S. H. Costa
- Medical Research Council Cancer Unit, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, University of Cambridge
- Marco Sciacovelli
- Medical Research Council Cancer Unit, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, University of Cambridge
- Benoit Rousseau
- Service Commun des Animaleries, Animalerie A2, University of Bordeaux
- Elodie Richard
- INSERM U1218, Institut Bergonié
- Pierre Vacher
- INSERM U1218, Institut Bergonié
- Carlos Parejo-Pérez
- Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla
- Emilie Bessede
- Bordeaux Research in Translational Oncology, INSERM U1053, Université de Bordeaux
- Christine Varon
- Bordeaux Research in Translational Oncology, INSERM U1053, Université de Bordeaux
- Pierre Soubeyran
- INSERM U1218, Institut Bergonié
- Christian Frezza
- Medical Research Council Cancer Unit, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, University of Cambridge
- Piedad del Socorro Murdoch
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Universidad Pablo de Olavide
- Victor H. Villar
- CRUK Beatson Institute
- Raúl V. Durán
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Universidad Pablo de Olavide
- DOI
- https://doi.org/10.1038/s41467-021-25079-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relevance to cancer therapeutics design.
