NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

Chenyu Li; Chenyi Xue; Qiaoyun Yang; Boon Chuan Low; Yih-Cherng Liou

doi:10.1038/ncomms10597

Nature Communications (Feb 2016)

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

Chenyu Li,
Chenyi Xue,
Qiaoyun Yang,
Boon Chuan Low,
Yih-Cherng Liou

Affiliations

Chenyu Li: Department of Biological Sciences, Faculty of Science, National University of Singapore
Chenyi Xue: Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
Qiaoyun Yang: Department of Biological Sciences, Faculty of Science, National University of Singapore
Boon Chuan Low: Department of Biological Sciences, Faculty of Science, National University of Singapore
Yih-Cherng Liou: Department of Biological Sciences, Faculty of Science, National University of Singapore

DOI: https://doi.org/10.1038/ncomms10597
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al. show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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