Communications Biology (Jan 2021)

Obese mother offspring have hepatic lipidic modulation that contributes to sex-dependent metabolic adaptation later in life

  • Christina Savva,
  • Luisa A. Helguero,
  • Marcela González-Granillo,
  • Daniela Couto,
  • Tânia Melo,
  • Xidan Li,
  • Bo Angelin,
  • Maria Rosário Domingues,
  • Claudia Kutter,
  • Marion Korach-André

DOI
https://doi.org/10.1038/s42003-020-01513-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Savva et al. investigate the sex dependent effect of maternal obesity on the metabolism of offspring. They find that metabolic changes are conferred on a sex basis, with males suffering from impaired lipid metabolism relative to females when born to obese mothers, using a lipidomic approach.