Classification of Proteomic MS Data as Bayesian Solution of an Inverse Problem

Abstract

The cells in an organism emit different amounts of proteins according to their clinical state (healthy/pathological, for instance). The resulting proteomic profile can be used for early detection, diagnosis, and therapy planning. In this paper, we study the classification of a proteomic sample from the point of view of an inverse problem with a joint Bayesian solution, called inversion-classification. We propose a hierarchical physical forward model and present encouraging results from both simulation and clinical data.

Keywords

• statistical signal processing
• inverse problems
• mathematical modelling
• classification algorithms
• probability
• proteins