Nature Communications (Apr 2019)
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
- Koichi Kikuchi,
- Daisuke Saigusa,
- Yoshitomi Kanemitsu,
- Yotaro Matsumoto,
- Paxton Thanai,
- Naoto Suzuki,
- Koki Mise,
- Hiroaki Yamaguchi,
- Tomohiro Nakamura,
- Kei Asaji,
- Chikahisa Mukawa,
- Hiroki Tsukamoto,
- Toshihiro Sato,
- Yoshitsugu Oikawa,
- Tomoyuki Iwasaki,
- Yuji Oe,
- Tomoya Tsukimi,
- Noriko N. Fukuda,
- Hsin-Jung HO,
- Fumika Nanto-Hara,
- Jiro Ogura,
- Ritsumi Saito,
- Shizuko Nagao,
- Yusuke Ohsaki,
- Satoshi Shimada,
- Takehiro Suzuki,
- Takafumi Toyohara,
- Eikan Mishima,
- Hisato Shima,
- Yasutoshi Akiyama,
- Yukako Akiyama,
- Mariko Ichijo,
- Tetsuro Matsuhashi,
- Akihiro Matsuo,
- Yoshiaki Ogata,
- Ching-Chin Yang,
- Chitose Suzuki,
- Matthew C. Breeggemann,
- Jurgen Heymann,
- Miho Shimizu,
- Susumu Ogawa,
- Nobuyuki Takahashi,
- Takashi Suzuki,
- Yuji Owada,
- Shigeo Kure,
- Nariyasu Mano,
- Tomoyoshi Soga,
- Takashi Wada,
- Jeffrey B. Kopp,
- Shinji Fukuda,
- Atsushi Hozawa,
- Masayuki Yamamoto,
- Sadayoshi Ito,
- Jun Wada,
- Yoshihisa Tomioka,
- Takaaki Abe
Affiliations
- Koichi Kikuchi
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Daisuke Saigusa
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Yoshitomi Kanemitsu
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Yotaro Matsumoto
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Paxton Thanai
- Waters Corporation
- Naoto Suzuki
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Koki Mise
- Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
- Hiroaki Yamaguchi
- Department of Pharmaceutical Sciences, Tohoku University Hospital
- Tomohiro Nakamura
- Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University
- Kei Asaji
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Chikahisa Mukawa
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Hiroki Tsukamoto
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Toshihiro Sato
- Department of Pharmaceutical Sciences, Tohoku University Hospital
- Yoshitsugu Oikawa
- Department of Pediatrics, Tohoku University Graduate School of Medicine
- Tomoyuki Iwasaki
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Yuji Oe
- Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences
- Tomoya Tsukimi
- Institute for Advanced Biosciences, Keio University
- Noriko N. Fukuda
- Institute for Advanced Biosciences, Keio University
- Hsin-Jung HO
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Fumika Nanto-Hara
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Jiro Ogura
- Department of Pharmaceutical Sciences, Tohoku University Hospital
- Ritsumi Saito
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Shizuko Nagao
- Education and Research Center of Animal Models for Human Diseases, Fujita Health University
- Yusuke Ohsaki
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Satoshi Shimada
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Takehiro Suzuki
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Takafumi Toyohara
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Eikan Mishima
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Hisato Shima
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Yasutoshi Akiyama
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Yukako Akiyama
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Mariko Ichijo
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Tetsuro Matsuhashi
- Department of Pediatrics, Tohoku University Graduate School of Medicine
- Akihiro Matsuo
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Yoshiaki Ogata
- Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine
- Ching-Chin Yang
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Chitose Suzuki
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Matthew C. Breeggemann
- Kidney Diseases Branch, NIDDK, NIH
- Jurgen Heymann
- Kidney Diseases Branch, NIDDK, NIH
- Miho Shimizu
- Department of Nephrology and Laboratory Medicine, Kanazawa University
- Susumu Ogawa
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Nobuyuki Takahashi
- Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences
- Takashi Suzuki
- Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine
- Yuji Owada
- Department of Organ Anatomy, Tohoku University Graduate School of Medicine
- Shigeo Kure
- Department of Pediatrics, Tohoku University Graduate School of Medicine
- Nariyasu Mano
- Department of Pharmaceutical Sciences, Tohoku University Hospital
- Tomoyoshi Soga
- Institute for Advanced Biosciences, Keio University
- Takashi Wada
- Department of Nephrology and Laboratory Medicine, Kanazawa University
- Jeffrey B. Kopp
- Kidney Diseases Branch, NIDDK, NIH
- Shinji Fukuda
- Institute for Advanced Biosciences, Keio University
- Atsushi Hozawa
- Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University
- Masayuki Yamamoto
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Sadayoshi Ito
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- Jun Wada
- Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
- Yoshihisa Tomioka
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences
- Takaaki Abe
- Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-09735-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.
