ChemistryOpen
(Jan 2023)
A Xanthan‐Gum‐Stabilized PEG‐Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential
Prem Pandey,
Supriya Chaturvedi,
Rutuja Gumathannavar,
Dr. Mandar M. Shirolkar,
Dr. Vijay Kanuru,
Prof. Dr. Atul Kulkarni,
Dr. Sang Hyun Moh
Affiliations
Prem Pandey
Symbiosis Center for Nanoscience and Nanotechnology (SCNN) Symbiosis International (Deemed University) (SIU) Lavale Pune 412115 Maharashtra India
Supriya Chaturvedi
Nuimance Phytovigyan Private Limited (NPPL) Anusha Enclave Pashan-Sus Road Pune 411021 Maharashtra India
Rutuja Gumathannavar
Symbiosis Center for Nanoscience and Nanotechnology (SCNN) Symbiosis International (Deemed University) (SIU) Lavale Pune 412115 Maharashtra India
Dr. Mandar M. Shirolkar
Symbiosis Center for Nanoscience and Nanotechnology (SCNN) Symbiosis International (Deemed University) (SIU) Lavale Pune 412115 Maharashtra India
Dr. Vijay Kanuru
Oncocur India Private Limited #1, Pitruchhaya, Sanghavi Corporate Park Govandi (E) Mumbai 400088 India
Prof. Dr. Atul Kulkarni
Symbiosis Center for Nanoscience and Nanotechnology (SCNN) Symbiosis International (Deemed University) (SIU) Lavale Pune 412115 Maharashtra India
Dr. Sang Hyun Moh
Plant Cell Research Institute of BIO-FD&C 509-512, Smartvalley A, 30 Songdomirae-ro, Yeonsu-gu Incheon 21990 South Korea
DOI
https://doi.org/10.1002/open.202200200
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Abstract We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5‐fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors.
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