Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Lin Wang; Junke Song; Ailin Liu; Bin Xiao; Sha Li; Zhang Wen; Yang Lu; Guanhua Du

doi:10.1007/s13659-020-00257-x

Natural Products and Bioprospecting (Sep 2020)

Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Lin Wang,
Junke Song,
Ailin Liu,
Bin Xiao,
Sha Li,
Zhang Wen,
Yang Lu,
Guanhua Du

Affiliations

Lin Wang: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Junke Song: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Ailin Liu: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Bin Xiao: Laboratory of Clinical Pharmacy, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University
Sha Li: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Zhang Wen: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Yang Lu: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Guanhua Du: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1007/s13659-020-00257-x
Journal volume & issue: Vol. 10, no. 5
pp. 271 – 283

Abstract

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Abstract Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.

Published in Natural Products and Bioprospecting

ISSN: 2192-2195 (Print); 2192-2209 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Science: Botany
Website: http://www.springer.com/13659

About the journal

Abstract

Keywords