Communications Biology (Jun 2021)
The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice
- Katrina A. Button-Simons,
- Sudhir Kumar,
- Nelly Carmago,
- Meseret T. Haile,
- Catherine Jett,
- Lisa A. Checkley,
- Spencer Y. Kennedy,
- Richard S. Pinapati,
- Douglas A. Shoue,
- Marina McDew-White,
- Xue Li,
- François H. Nosten,
- Stefan H. Kappe,
- Timothy J. C. Anderson,
- Jeanne Romero-Severson,
- Michael T. Ferdig,
- Scott J. Emrich,
- Ashley M. Vaughan,
- Ian H. Cheeseman
Affiliations
- Katrina A. Button-Simons
- Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame
- Sudhir Kumar
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Nelly Carmago
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Meseret T. Haile
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Catherine Jett
- Host Pathogen Interactions Program, Texas Biomedical Research Institute
- Lisa A. Checkley
- Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame
- Spencer Y. Kennedy
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Richard S. Pinapati
- Nimble Therapeutics
- Douglas A. Shoue
- Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame
- Marina McDew-White
- Disease Intervention and Prevention Program, Texas Biomedical Research Institute
- Xue Li
- Disease Intervention and Prevention Program, Texas Biomedical Research Institute
- François H. Nosten
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University
- Stefan H. Kappe
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Timothy J. C. Anderson
- Disease Intervention and Prevention Program, Texas Biomedical Research Institute
- Jeanne Romero-Severson
- Department of Biological Sciences, University of Notre Dame
- Michael T. Ferdig
- Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame
- Scott J. Emrich
- Univeristy of Tennessee
- Ashley M. Vaughan
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute
- Ian H. Cheeseman
- Host Pathogen Interactions Program, Texas Biomedical Research Institute
- DOI
- https://doi.org/10.1038/s42003-021-02210-1
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Button-Simons et al. report on two different genetic crosses of Plasmodium falciparum derived from Asian and African origin parasites, and generate large numbers of recombinant progeny. These crosses are characterized and have the potential to map biologically important traits across parasite genomes.
