Nature Communications (Aug 2017)

Ensa controls S-phase length by modulating Treslin levels

  • Sophie Charrasse,
  • Aicha Gharbi-Ayachi,
  • Andrew Burgess,
  • Jorge Vera,
  • Khaled Hached,
  • Peggy Raynaud,
  • Etienne Schwob,
  • Thierry Lorca,
  • Anna Castro

DOI
https://doi.org/10.1038/s41467-017-00339-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

The Greatwall/Ensa/PP2A-B55 pathway controls mitotic substrate phosphorylation and mitotic entry. Here the authors show that cells regulate S phase duration by controlling the ubiquitin-proteasome degradation of Treslin in a Gwl/Ensa-dependent pathway.