Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration
Elena N. Dresvyanina,
Nurjemal A. Tagandurdyyeva,
Vera V. Kodolova-Chukhontseva,
Irina P. Dobrovol’skaya,
Almaz M. Kamalov,
Yulia A. Nashchekina,
Alexey V. Nashchekin,
Alexey G. Ivanov,
Galina Yu. Yukina,
Vladimir E. Yudin
Affiliations
Elena N. Dresvyanina
Institute of Textile and Fashion, Saint Petersburg State University of Industrial Technologies and Design, B. Morskaya Str., 18, Saint Petersburg 191186, Russia
Nurjemal A. Tagandurdyyeva
Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, Russia
Vera V. Kodolova-Chukhontseva
Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, Russia
Irina P. Dobrovol’skaya
Institute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, Russia
Almaz M. Kamalov
Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, Russia
Yulia A. Nashchekina
Institute of Cytology Russian Academy of Sciences, Tikhoretsky Ave., 4, Saint Petersburg 194064, Russia
Alexey V. Nashchekin
Ioffe Institute, Polytekhnicheskaya Str., 26, Saint Petersburg 194021, Russia
Alexey G. Ivanov
Institute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, Russia
Galina Yu. Yukina
Pavlov First Saint Petersburg State Medical University, L’va Tolstogo Str. 6-8, Saint Petersburg 197022, Russia
Vladimir E. Yudin
Institute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, Russia
This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber.
