The Increased Release Kinetics of Quercetin from Superparamagnetic Nanocarriers in Dialysis

Abstract

The actual cumulative mass of released quercetin from nanoparticles within the dialysis membrane was determined under the influence of external stationary and alternating magnetic fields. We have shown that the control of the release kinetics of quercetin from MNPs, i.e., the distribution of quercetin between the nanoparticles and the suspension within the membrane, can be tuned by the simple combination of stationary and alternating magnetic fields. Under non-sink conditions, the proportion of quercetin in the suspension inside the membrane is increased toward the nanoparticles, resulting in the increased release of quercetin. The results obtained could be applied to the release of insoluble flavonoids in aqueous suspensions in general.

Keywords

• release kinetics
• superparamagnetism
• stationary magnetic field
• alternating magnetic fields
• magnetic nanoparticles
• quercetin