Nature Communications (Aug 2020)
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
- Patricia R. Pitrez,
- Luís Estronca,
- Luís Miguel Monteiro,
- Guillem Colell,
- Helena Vazão,
- Deolinda Santinha,
- Karim Harhouri,
- Daniel Thornton,
- Claire Navarro,
- Anne-Laure Egesipe,
- Tânia Carvalho,
- Rodrigo L. Dos Santos,
- Nicolas Lévy,
- James C. Smith,
- João Pedro de Magalhães,
- Alessandro Ori,
- Andreia Bernardo,
- Annachiara De Sandre-Giovannoli,
- Xavier Nissan,
- Anna Rosell,
- Lino Ferreira
Affiliations
- Patricia R. Pitrez
- Center for Neuroscience and Cell Biology, University of Coimbra
- Luís Estronca
- Center for Neuroscience and Cell Biology, University of Coimbra
- Luís Miguel Monteiro
- Center for Neuroscience and Cell Biology, University of Coimbra
- Guillem Colell
- Neurovascular Research Laboratory, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona
- Helena Vazão
- Center for Neuroscience and Cell Biology, University of Coimbra
- Deolinda Santinha
- Center for Neuroscience and Cell Biology, University of Coimbra
- Karim Harhouri
- Aix Marseille Univ, INSERM, MMG
- Daniel Thornton
- Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool
- Claire Navarro
- Aix Marseille Univ, INSERM, MMG
- Anne-Laure Egesipe
- CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases
- Tânia Carvalho
- IMM, Instituto de Medicina Molecular, Universidade de Lisboa
- Rodrigo L. Dos Santos
- 25 Cambridge Science Park, Mogrify Ltd
- Nicolas Lévy
- Aix Marseille Univ, INSERM, MMG
- James C. Smith
- Developmental Biology Laboratory, Francis Crick Institute
- João Pedro de Magalhães
- Center for Neuroscience and Cell Biology, University of Coimbra
- Alessandro Ori
- Leibniz Institute on Aging - Fritz Lipmann Institute
- Andreia Bernardo
- Developmental Biology Laboratory, Francis Crick Institute
- Annachiara De Sandre-Giovannoli
- Aix Marseille Univ, INSERM, MMG
- Xavier Nissan
- CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases
- Anna Rosell
- Neurovascular Research Laboratory, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona
- Lino Ferreira
- Center for Neuroscience and Cell Biology, University of Coimbra
- DOI
- https://doi.org/10.1038/s41467-020-17901-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that inhibition of metalloprotease 13 may reduce smooth muscle cell loss.
