γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Nejat Akar; Kadir Sipahi; Ece Akar; Erkan Yilmaz

doi:10.4081/thal.2014.1935

Thalassemia Reports (Sep 2014)

γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Nejat Akar,
Kadir Sipahi,
Ece Akar,
Erkan Yilmaz

Affiliations

Nejat Akar: Department of Pediatric Molecular Genetics, Ankara University, Ankara
Kadir Sipahi: Department of Pediatric Molecular Genetics, Ankara University, Ankara
Ece Akar: Department of Pediatric Molecular Genetics, Ankara University, Ankara
Erkan Yilmaz: Department of Pediatric Molecular Genetics, Ankara University, Ankara

DOI: https://doi.org/10.4081/thal.2014.1935
Journal volume & issue: Vol. 4, no. 2

Abstract

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Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.

hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.

Published in Thalassemia Reports

ISSN: 2039-4365 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://www.mdpi.com/journal/thalassrep

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