Pediatric Hematology Oncology Journal (Mar 2017)

Transient abnormal myelopoiesis: A case series and review of the literature

  • Vandana Baloda,
  • Papagudi G. Subramanian,
  • Yajamanam Badrinath,
  • Ashok Kumar,
  • Pratibha S. Kadam Amare,
  • Shripad D. Banavali,
  • Brijesh Arora,
  • Sumeet Gujral

DOI
https://doi.org/10.1016/j.phoj.2017.06.001
Journal volume & issue
Vol. 2, no. 1
pp. 14 – 18

Abstract

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Transient abnormal myelopoiesis (TAM) is a rare and unique disorder affecting Down syndrome (DS) newborns. This case series presents 5 cases of Down syndrome with TAM diagnosed during 2007–2015 with detailed analysis of immunophenotypic data of each case. CD34, CD13, CD33, CD117, CD41, CD61, CD7 and HLA-DR are useful markers for characterization of blasts of TAM.

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