Nature Communications (Aug 2016)

Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila

  • Ying Liu,
  • Qinglan Ge,
  • Brian Chan,
  • Hanhan Liu,
  • Shree Ram Singh,
  • Jacob Manley,
  • Jae Lee,
  • Ann Marie Weideman,
  • Gerald Hou,
  • Steven X. Hou

DOI
https://doi.org/10.1038/ncomms12149
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GSC fate.