Clinical, Cosmetic and Investigational Dermatology (May 2025)

Rheology as a Tool to Investigate the Degradability of Hyaluronic Acid Dermal Fillers

  • Grimaldi G,
  • Galasso G,
  • Capillo MC,
  • Alonci G,
  • Bighetti S,
  • Bettolini L,
  • Sommatis S,
  • Mocchi R,
  • Carugno A,
  • Zerbinati N

Journal volume & issue
Vol. Volume 18, no. Issue 1
pp. 1349 – 1358

Abstract

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Giulia Grimaldi,1 Giulia Galasso,1 Maria Chiara Capillo,1 Giuseppe Alonci,1 Stefano Bighetti,2 Luca Bettolini,2 Sabrina Sommatis,1 Roberto Mocchi,1 Andrea Carugno,3 Nicola Zerbinati4 1UB-CARE S.r.l.-Spin-Off, University of Pavia, Pavia, Italy; 2Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; 3Department of Medicine and Surgery, University of Insubria, Varese, Italy; 4University of Insubria, Department of Medicine and Technology Innovation, Varese, ItalyCorrespondence: Stefano Bighetti, Dermatology Department, Piazzale Spedali Civili 1, Brescia, 25123, Italy, Tel +39 030 3995301, Fax +39 030 399505, Email [email protected]: In the current landscape of aesthetic medicine, the use of hyaluronic acid (HA)-based dermal fillers is increasingly prevalent. Although HA is widely acknowledged for its safety and efficacy the study of its degradability represents a critical aspect in ensuring safety.Methods: Rotational rheology was chosen to study the HA-based fillers interaction with hyaluronidase enzyme; this allows to establish a correlation between the viscoelastic parameters of the sample and its degradation.Results: The obtained results indicate that the products exhibit sensitivity to the enzyme and that the rheological parameters vary depending on the contact time and dosage of administration.Conclusion: Our findings propose a standardized rheological protocol for assessing the degradability of HA-based dermal fillers, offering an alternative to existing methods.Keywords: hyaluronic acid, adverse drug reaction, aesthetic dermatology, cosmetic dermatology

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