Nature Communications (Nov 2018)

Vapor detection and discrimination with a panel of odorant receptors

  • Hitoshi Kida,
  • Yosuke Fukutani,
  • Joel D. Mainland,
  • Claire A. de March,
  • Aashutosh Vihani,
  • Yun Rose Li,
  • Qiuyi Chi,
  • Akemi Toyama,
  • Linda Liu,
  • Masaharu Kameda,
  • Masafumi Yohda,
  • Hiroaki Matsunami

DOI
https://doi.org/10.1038/s41467-018-06806-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Biomimetic “noses” have been proposed to replace trained animals for chemical detection. Here the authors select 31 mouse olfactory receptors (ORs), based on a large cell-based screen of >800 ORs against seven chemicals, to build an OR-based sensor able to discriminate structurally similar compounds.