PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)

Abstract

The review presents and discusses modern conceptions about causes of development, existing ways of prevention and correction of liver failure. Unsatisfactory effectiveness of traditional infusion and medicinal therapy, as well as low availability of extracorporal detoxification and liver transplantation methods generates a need for search of brand new patogeneticaly substantiated methods of treatment of liver failure. The data about pathogenesis of liver failure and about sanogenesis and regeneration processes are presented. Hepatocite growth factor plays leading role in that processes, most important effects of present cytokine are considered. Next part of the article describes principles, mechanism of action and results of experimental use of cell therapy method. This method has shown effectiveness in animal models and it is perspective for further improvement, but not allowed for clinical use. That's why authors consider that the most perspective solution is creation of new drug, containing regulatory peptides of liver.

Keywords

• liver failure
• biotechnology
• cell transplantation