Nature Communications (May 2021)

Neural network aided approximation and parameter inference of non-Markovian models of gene expression

  • Qingchao Jiang,
  • Xiaoming Fu,
  • Shifu Yan,
  • Runlai Li,
  • Wenli Du,
  • Zhixing Cao,
  • Feng Qian,
  • Ramon Grima

DOI
https://doi.org/10.1038/s41467-021-22919-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Cells are complex systems that make decisions biologists struggle to understand. Here, the authors use neural networks to approximate the solution of mathematical models that capture the history and randomness of biochemical processes in order to understand the principles of transcription control.