Polymorphisms in autophagy genes and active pulmonary tuberculosis susceptibility in Romania

Abstract

Autophagy, a homeostatic process involved in nutrient regeneration and immune responses, may be involved in intracellular killing of M. tuberculosis. Several studies linked variation in autophagy genes with susceptibility to pulmonary tuberculosis, but others did not confirm these findings.

Keywords

• tuberculosis
• gene polymorphism
• autophagy
• innate immune system
• allele