Radiographic changes in children with primary immunodeficiency

Abstract

Background: Although we have epidemiological information on primary immunodeficiencies (PID), the available information is meager in Mexico. Objective: To provide epidemiological information on the delay in the diagnosis of PID and its correlation to chronic lung damage Material and method: A retrospective, analytical study was done in patients 0-18 year old age diagnosed with PID for 11 years at the HIMFG (Hospital Infantil de Mexico Federico Gomez). The variables studied were: age at symptom onset, age at diagnosis, time from onset of symptoms to diagnosis, number of previous pneumonias and studies with radiographic chronic lung damage data. Results: 48 patients were obtained after meeting inclusion criteria; 33 showed lung damage at diagnosis, antibody deficiency being the most affected group. Relating age of onset of symptoms and the time difference of the onset of symptoms to diagnosis showed a strong correlation (p 0.80). A moderate correlation between the observed time difference vs number of pneumonias (p=0.005, Rho=0.495) and correlation between number of pneumonia and lung damage was highly significant (p 2) must make suspect the diagnosis of PID, as recommended in the literature.

Keywords

• inmunodeficiencias primarias
• daño pulmonar crónico
• diagnóstico tardío
• neumonía