npj Digital Medicine (Mar 2025)
Leveraging electronic medical records to evaluate a computerized decision support system for staphylococcus bacteremia
- Julia Palm,
- Ssuhir Alaid,
- Danny Ammon,
- Julian Brandes,
- Andreas Dürschmid,
- Claudia Fischer,
- Jonas Fortmann,
- Kristin Friebel,
- Sarah Geihs,
- Anne-Kathrin Hartig,
- Donghui He,
- Andrew J. Heidel,
- Petra Hetfeld,
- Roland Ihle,
- Suzanne Kahle,
- Verena Koi,
- Margarethe Konik,
- Frauke Kretzschmann,
- Henner Kruse,
- Norman Lippmann,
- Christoph Lübbert,
- Gernot Marx,
- Rafael Mikolajczyk,
- Anne Mlocek,
- Stefan Moritz,
- Christoph Müller,
- Susanne Müller,
- Ariadna Pérez Garriga,
- Lo An Phan-Vogtmann,
- Diana Pietzner,
- Mathias W. Pletz,
- Mario Popp,
- Maike Rebenstorff,
- Jonas Renz,
- Florian Rißner,
- Rainer Röhrig,
- Kutaiba Saleh,
- Sebastian G. Schönherr,
- Cord Spreckelsen,
- Anja Stempel,
- Abel Stolz,
- Eric Thomas,
- Susanne Thon,
- Daniel Tiller,
- Sebastian Uschmann,
- Sebastian Wendt,
- Thomas Wendt,
- Philipp Winnekens,
- Oliver Witzke,
- Stefan Hagel,
- André Scherag
Affiliations
- Julia Palm
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Ssuhir Alaid
- IT Department, Data Integration Center, University Hospital Halle
- Danny Ammon
- Data Integration Center, Jena University Hospital
- Julian Brandes
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Andreas Dürschmid
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Claudia Fischer
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Jonas Fortmann
- Institute of Medical Informatics, University Hospital RWTH Aachen
- Kristin Friebel
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Sarah Geihs
- IT Department, Data Integration Center, University Hospital Aachen
- Anne-Kathrin Hartig
- IT Department, Data Integration Center, University Hospital Halle
- Donghui He
- Central IT Department, Data Integration Center, University Hospital Essen
- Andrew J. Heidel
- Data Integration Center, Jena University Hospital
- Petra Hetfeld
- Department of Intensive Care Medicine and Intermediate Care, University Hospital RWTH Aachen
- Roland Ihle
- Central IT Department, Data Integration Center, University Hospital Essen
- Suzanne Kahle
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Verena Koi
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Margarethe Konik
- Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen
- Frauke Kretzschmann
- IT Department, Data Integration Center, University Hospital Aachen
- Henner Kruse
- Data Integration Center, Jena University Hospital
- Norman Lippmann
- Institute for Medical Microbiology and Virology, University Hospital Leipzig
- Christoph Lübbert
- Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, University Hospital Leipzig
- Gernot Marx
- Department of Intensive Care Medicine and Intermediate Care, University Hospital RWTH Aachen
- Rafael Mikolajczyk
- Institute of Medical Epidemiology, Biometrics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg
- Anne Mlocek
- Institute for Medical Microbiology and Virology, University Hospital Leipzig
- Stefan Moritz
- Section of Clinical Infectious Diseases, University Hospital Halle
- Christoph Müller
- IT Department, Data Integration Center, University Hospital Aachen
- Susanne Müller
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Ariadna Pérez Garriga
- Institute of Medical Informatics, University Hospital RWTH Aachen
- Lo An Phan-Vogtmann
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Diana Pietzner
- IT Department, Data Integration Center, University Hospital Halle
- Mathias W. Pletz
- Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena
- Mario Popp
- Section of Clinical Infectious Diseases, University Hospital Halle
- Maike Rebenstorff
- Institute for Medical Microbiology and Virology, University Hospital Leipzig
- Jonas Renz
- Data Integration Center, Jena University Hospital
- Florian Rißner
- Center for Clinical Studies, Friedrich-Schiller-University Jena
- Rainer Röhrig
- Institute of Medical Informatics, University Hospital RWTH Aachen
- Kutaiba Saleh
- Data Integration Center, Jena University Hospital
- Sebastian G. Schönherr
- Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, University Hospital Leipzig
- Cord Spreckelsen
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Anja Stempel
- Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen
- Abel Stolz
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Eric Thomas
- Data Integration Center, Jena University Hospital
- Susanne Thon
- Institute of Medical Microbiology, Jena University Hospital
- Daniel Tiller
- IT Department, Data Integration Center, University Hospital Halle
- Sebastian Uschmann
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- Sebastian Wendt
- Hospital Hygiene Staff Unit, University Hospital Halle (Saale)
- Thomas Wendt
- Center for Medical Informatics, Data Integration Center, University of Leipzig Medical Center
- Philipp Winnekens
- Central IT Department, Data Integration Center, University Hospital Essen
- Oliver Witzke
- Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen
- Stefan Hagel
- Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena
- André Scherag
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital
- DOI
- https://doi.org/10.1038/s41746-025-01569-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Abstract Infectious disease specialists (IDS) improve outcomes of patients with Staphylococcus bacteremia, but immediate IDS access is not always guaranteed. We investigated whether a care-integrated computerized decision support system (CDSS) can safely enhance the standard of care (SOC) for these patients. We conducted a multicenter, noninferiority, interventional stepped-wedge cluster randomized controlled trial relying on the data integration centers at five university hospitals. By this means, electronic medical records can be used for part of the trial documentation. We analyzed 5056 patients from 134 wards (Staphylococcus aureus (SAB): n = 812, coagulase-negative staphylococci (CoNS): n = 4244) and found that the CDSS was noninferior to the SOC for hospital mortality in all patients. Noninferiority regarding the 90-day mortality/relapse in SAB patients was not observed and there was no evidence for differences in vancomycin usage among CoNS patients. Despite low reported usage, physicians rated the CDSS’s usability favorably. Trial registration: drks.de; Identifier: DRKS00014320; Registration Date: 2019-05-06.
