CLINICOPATHOGENETIC CHARACTERISTICS OF CARDIORENAL SYNDROME IN NON-ALCOHOLIC FATTY DISEASE OF THE LIVER

Abstract

To study clinicopathogenetic characteristics of cardiorenal syndrome (CRS) in non-alcoholic fatty disease of the liver (nAFDL). Material and methods. Insulin resistance markers, plasma ієрtin and serum adiponectin concentrations, albuminuria, intima-media thickness (IMT) of the common carotid artery (CCA) were assessed in 80 patients with metabolic syndrome (60 males and 20 females, mean age 44+-11 years) and NAFDL. Results. With increasing signs of affection of target organs in NAFDL there was a trend to a significant rise in detection of chronic kidney disease (CKD) and carotid artery atherosclerosis, aggravation of albuminuria and CCA IMT, lowering of glomerular filtration rate. Leptinemia was maximal in CKD patients and directly correlated with albuminuria. Patients with CCA atherosclerosis had a significant fall of serum adiponectin which negatively correlated with CCA IMT. The latter positively correlated with insulinemia, a C-peptide plasma level and HOMA index. Serum concentration of adiponectin positively correlated with DeRitis index. Conclusion. CRS in NAFDL is characterized with frequent development of CKD and CCA atherosclerosis defined also by unbalance of adiponectin and leptin production.

Keywords

• non-alcoholic fatty disease of the liver
• metabolic syndrome
• cardiorenal syndrome
• leptin
• adiponectin
• insulin resistance