Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Dec 2004)
Evaluation of clinical effects of local form of Doxycycline gel with Scaling/root planning (SRP) in treatment of adult periodontitis
Abstract
Background and Objective: In recent years, using of local antibiotic as an adjunctive treatment in periodontitis has been considered. The aim of this study was to survey the local effects of Doxycycline with scaling/root planning in treatment of adult periodontitis. Methods: This experimental study was accomplished on 5 patients with adult periodontitis. The patients were chosen with at least three pockets with depth of approximately ≥4mm and bleeding in each quadrant. After initial preparation and scaling, the jaws were divided into 3 parts upper right: Receiving Doxycycline gel (Case group), upper left: Receiving base gel (Control group) and lower right: Do not received any gel (Sham group). One, three and six months after beginning the study, all the indices were measured again and finally all data were analyzed by statistical tests. Findings: In this study after 6 months, reduction of pocket depth and clinical attachment level (CAL) in case, control and sham groups were difference. Mean of pocket depth in case group was reduced from 2.3±0.5 mm to 1.5±0.6 mm after 3 months, and 1.9±0.6 mm after 6 months, and in control group from 2.2±0.8 mm to 1.6±0.6 mm after 3 months, and 1.8±0.7 mm after 6 months, these differences for clinical attachment level in buccal side of the teeth in 3 groups were significant (P<0.05). Also, there were differences in bleeding index in 3 groups. As for mobility and plaque index there was not any significant difference between the groups. Conclusion: Totally, the outcome of Doxycycline gel and SRR treatment group was satisfied than the other groups during 6 months, although the effects were not too long.
