Frontiers in Cellular and Infection Microbiology (Apr 2019)

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

  • Osmel Fleitas Martínez,
  • Osmel Fleitas Martínez,
  • Marlon Henrique Cardoso,
  • Marlon Henrique Cardoso,
  • Marlon Henrique Cardoso,
  • Suzana Meira Ribeiro,
  • Octavio Luiz Franco,
  • Octavio Luiz Franco,
  • Octavio Luiz Franco

DOI
https://doi.org/10.3389/fcimb.2019.00074
Journal volume & issue
Vol. 9

Abstract

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Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Among the innovative proposed strategies, anti-virulence therapy has been envisioned as a promising alternative for effective control of the emergence and spread of resistant pathogens. This review presents some of the anti-virulence strategies that are currently being developed, it will cover strategies focused on quench pathogen quorum sensing (QS) systems, disassemble of bacterial functional membrane microdomains (FMMs), disruption of biofilm formation and bacterial toxin neutralization.

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