Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Claire B. Péan; Mark Schiebler; Sharon W. S. Tan; Jessica A. Sharrock; Katrin Kierdorf; Karen P. Brown; M. Charlotte Maserumule; Shinelle Menezes; Martina Pilátová; Kévin Bronda; Pierre Guermonprez; Brian M. Stramer; R. Andres Floto; Marc S. Dionne

doi:10.1038/ncomms14642

Nature Communications (Mar 2017)

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Claire B. Péan,
Mark Schiebler,
Sharon W. S. Tan,
Jessica A. Sharrock,
Katrin Kierdorf,
Karen P. Brown,
M. Charlotte Maserumule,
Shinelle Menezes,
Martina Pilátová,
Kévin Bronda,
Pierre Guermonprez,
Brian M. Stramer,
R. Andres Floto,
Marc S. Dionne

Affiliations

Claire B. Péan: and Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London
Mark Schiebler: University of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular Biology
Sharon W. S. Tan: Centre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College London
Jessica A. Sharrock: and Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London
Katrin Kierdorf: and Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London
Karen P. Brown: University of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular Biology
M. Charlotte Maserumule: University of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular Biology
Shinelle Menezes: Centre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College London
Martina Pilátová: Randall Division of Cell and Molecular Biophysics, King’s College London
Kévin Bronda: Centre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College London
Pierre Guermonprez: Centre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College London
Brian M. Stramer: Randall Division of Cell and Molecular Biophysics, King’s College London
R. Andres Floto: University of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular Biology
Marc S. Dionne: and Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London

DOI: https://doi.org/10.1038/ncomms14642
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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