Nature Communications (May 2021)

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

  • Robert P. Hayes,
  • Mee Ra Heo,
  • Mark Mason,
  • John Reid,
  • Christine Burlein,
  • Kira A. Armacost,
  • David M. Tellers,
  • Izzat Raheem,
  • Anthony W. Shaw,
  • Edward Murray,
  • Philip M. McKenna,
  • Pravien Abeywickrema,
  • Sujata Sharma,
  • Stephen M. Soisson,
  • Daniel Klein

DOI
https://doi.org/10.1038/s41467-021-23312-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 7

Abstract

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Various herpesvirus therapeutics target the viral DNA polymerase. Here, the authors present the crystal structure of herpesvirus polymerase in the elongating state with bound primer-template DNA and the broad-spectrum non-nucleoside inhibitor PNU-183792, which is of interest for further drug design.