Nature Communications (May 2021)
Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase
Abstract
Various herpesvirus therapeutics target the viral DNA polymerase. Here, the authors present the crystal structure of herpesvirus polymerase in the elongating state with bound primer-template DNA and the broad-spectrum non-nucleoside inhibitor PNU-183792, which is of interest for further drug design.